Advances in Studies on Recombinant Adeno-associated Virus Vector
نویسندگان
چکیده
منابع مشابه
Herpes Simplex Virus Clearance during Purification of a Recombinant Adeno-associated Virus Serotype 1 Vector.
Gene delivery vectors based on adeno-associated virus (AAV) have potential utility in the treatment of many genetic disorders. Current AAV vector manufacturing methods employ helper viruses to deliver functions needed to produce replication-defective recombinant AAV (rAAV) vectors, and clearance of infectious helper virus from the drug substance is essential for ensuring the safety of rAAV-base...
متن کاملModified infusion procedures affect recombinant adeno-associated virus vector type 2 transduction in the liver.
Recombinant adeno-associated virus (rAAV) vectors have therapeutic potential for the treatment of several types of liver diseases including hepato-deficiency disorders. Most of the preclinical and clinical applications involve the use of adeno-associated vector serotype 2 (AAV-2). However, when this vector is delivered at high doses into the portal vein or hepatic artery, a relatively small num...
متن کاملDisease-inducible transgene expression from a recombinant adeno-associated virus vector in a rat arthritis model.
Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting 1% of the world's population, with significant morbidity and mortality. In this study, we investigated a recombinant adeno-associated virus (rAAV) vector for its potential application in RA gene therapy. rAAV encoding Escherichia coli beta-galactosidase was injected into rat joints which had already been induced into acute art...
متن کاملExtrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo.
Recombinant adeno-associated virus (rAAV) vectors stably transduce hepatocytes in experimental animals. Although the vector genomes are found both as extrachromosomes and as chromosomally integrated forms in hepatocytes, the relative proportion of each has not yet been clearly established. Using an in vivo assay based on the induction of hepatocellular regeneration via a surgical two-thirds par...
متن کاملGeneration of infectious recombinant Adeno-associated virus in Saccharomyces cerevisiae
The yeast Saccharomyces cerevisiae has been successfully employed to establish model systems for a number of viruses. Such model systems are powerful tools to study the virus biology and in particular for the identification and characterization of host factors playing a role in the viral infection cycle. Adeno-associated viruses (AAV) are heavily studied due to their use as gene delivery vector...
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ژورنال
عنوان ژورنال: Asian Journal of Animal and Veterinary Advances
سال: 2012
ISSN: 1683-9919
DOI: 10.3923/ajava.2012.1255.1260